Basic Information
VIS ID
TVIS20000147
Fusion event
HPV-PBX1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV18
Reference genome
AY262282.1
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
164752044/164782807 (Hg38)
End
164752044/164782807 (Hg38)
Location type
Intronic
Target gene
PBX1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-877-3p ; hsa-mir-149-5p ; hsa-mir-196b-5p ; hsa-mir-198 ; hsa-mir-1247-3p ; hsa-mir-3074-5p ; hsa-mir-4722-3p ; hsa-mir-617 ; hsa-mir-6505-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6882-3p
Nearest miRNA
hsa-mir-101-1/Upstream/2440167; hsa-mir-1182/Downstream/1125114;
Nearest TSS
ENST00000473358/Upstream/8166; ENST00000559560/Downstream/4836;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/206127, chr1-CpG: 29/Downstream/334712
Nearest cancer related gene
PBX1(OG, No orient, 0)
Upstream sequence
CACTGGATGTCCTGGAAGCTCTTCTTAATGGGCTGTATTGGTCAAGAGTAGATCTCACTCATCTCGATGATGGTGGTGAGTTGAGATAACTTATATCGTG
Downstream sequence
AATCTTGAGGTTGGGGGTTACTACTTCTTTCAGGAAGAGCCTCCTGCAGCAGCTGCCAAGTCAGGAGAAGGCCTTAGAGTTCTCACCAGCCGAGCCCCTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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