Basic Information
VIS ID
TVIS20000167
Fusion event
HPV-IGF1R integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr15
Cytoband
q26.3
Reference genome
End
99440819/98897590 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-133b ; hsa-mir-145-5p ; hsa-mir-7-5p ; hsa-mir-138-5p ; hsa-mir-194-5p ; hsa-mir-99a-5p ; hsa-mir-223-3p ; hsa-mir-100-5p ; hsa-mir-497-5p ; hsa-mir-152-3p ; hsa-mir-139-5p ; hsa-mir-376c-3p ; hsa-mir-376a-3p ; hsa-mir-181b-5p ; hsa-mir-383-5p ; hsa-mir-335-5p ; hsa-mir-215-5p ; hsa-mir-183-5p ; hsa-mir-182-5p ; hsa-mir-196a-5p ; hsa-mir-192-5p ; hsa-mir-30a-5p ; hsa-let-7d-5p ; hsa-mir-1226-3p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-34a-5p ; hsa-mir-92a-3p ; hsa-let-7e-5p ; hsa-mir-125b-2-3p ; hsa-let-7c-5p ; hsa-mir-16-5p ; hsa-mir-630 ; hsa-let-7b-5p ; hsa-mir-143-3p ; hsa-mir-133a-3p ; hsa-mir-140-5p ; hsa-mir-150-3p ; hsa-mir-375 ; hsa-mir-511-3p ; hsa-mir-548n ; hsa-mir-548t-5p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-548at-5p ; hsa-mir-548az-5p ; hsa-let-7a-2-3p ; hsa-let-7g-3p ; hsa-mir-503-5p ; hsa-mir-4670-3p ; hsa-mir-583 ; hsa-mir-885-5p ; hsa-mir-4668-5p ; hsa-mir-6124 ; hsa-mir-7151-5p ; hsa-let-7a-5p ; hsa-let-7f-5p ; hsa-mir-33a-3p ; hsa-mir-98-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-577 ; hsa-mir-1294 ; hsa-mir-3927-3p ; hsa-mir-3935 ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-5586-3p ; hsa-mir-6740-5p ; hsa-mir-6831-5p ; hsa-mir-1275 ; hsa-mir-4665-5p ; hsa-mir-3919 ; hsa-mir-8485 ; hsa-mir-625-5p ; hsa-mir-3148 ; hsa-mir-4641 ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-302a-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-302d-3p ; hsa-mir-372-3p ; hsa-mir-373-3p ; hsa-mir-520e ; hsa-mir-520a-3p ; hsa-mir-520b ; hsa-mir-520c-3p ; hsa-mir-520d-3p ; hsa-mir-1253 ; hsa-mir-302e ; hsa-mir-4299 ; hsa-mir-3646 ; hsa-mir-3662 ; hsa-mir-6770-5p ; hsa-mir-7855-5p ; hsa-mir-99b-5p ; hsa-mir-378a-3p ; hsa-mir-224-3p ; hsa-mir-522-3p ; hsa-mir-1468-3p ; hsa-mir-885-3p ; hsa-mir-3613-3p ; hsa-mir-190a-3p ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-548d-3p ; hsa-mir-548h-3p ; hsa-mir-548z ; hsa-mir-548ac ; hsa-mir-548as-3p ; hsa-mir-548bb-3p ; hsa-mir-5681a ; hsa-mir-34a-3p ; hsa-mir-539-5p ; hsa-mir-1827 ; hsa-mir-1910-3p ; hsa-mir-3617-3p ; hsa-mir-6511a-5p ; hsa-mir-8060 ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-3125 ; hsa-mir-3916 ; hsa-mir-6859-5p ; hsa-mir-592 ; hsa-mir-597-5p ; hsa-mir-520a-5p ; hsa-mir-525-5p ; hsa-mir-2467-3p ; hsa-mir-185-5p ; hsa-mir-206 ; hsa-mir-21-5p ; hsa-mir-26b-5p ; hsa-mir-486-5p ; hsa-mir-218-5p ; hsa-mir-4535 ; hsa-mir-4800-5p ; hsa-mir-8071 ; hsa-mir-6745 ; hsa-mir-363-5p ; hsa-mir-8085 ; hsa-mir-3175 ; hsa-mir-6731-5p ; hsa-mir-659-5p ; hsa-mir-492 ; hsa-mir-6861-3p ; hsa-mir-6804-5p ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-7109-5p ; hsa-mir-4789-5p ; hsa-mir-466 ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-202-3p ; hsa-mir-3163 ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-340-5p ; hsa-mir-4539 ; hsa-mir-3200-5p ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-3191-5p ; hsa-mir-6873-3p ; hsa-mir-7978 ; hsa-mir-494-3p ; hsa-mir-4456 ; hsa-mir-548q ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-518c-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-4423-3p ; hsa-mir-449c-5p ; hsa-mir-34b-5p ; hsa-mir-2682-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-551b-5p ; hsa-mir-548c-3p ; hsa-mir-675-3p ; hsa-mir-223-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-4655-5p ; hsa-mir-224-5p ; hsa-mir-502-5p ; hsa-mir-3941 ; hsa-mir-3124-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-4433b-5p ; hsa-mir-203a-3p ; hsa-mir-6794-3p ; hsa-mir-377-3p ; hsa-mir-4433a-5p ; hsa-mir-342-3p ; hsa-mir-6884-3p ; hsa-mir-4639-3p ; hsa-mir-4511 ; hsa-mir-629-3p ; hsa-mir-3180-5p ; hsa-mir-488-5p ; hsa-mir-7161-3p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-570-3p ; hsa-mir-125b-1-3p ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-6727-5p ; hsa-mir-6084 ; hsa-mir-6762-3p ; hsa-mir-4755-3p ; hsa-mir-6774-5p ; hsa-mir-635 ; hsa-mir-4508 ; hsa-mir-6775-5p ; hsa-mir-5090 ; hsa-mir-10b-3p ; hsa-mir-6867-5p ; hsa-mir-5003-5p ; hsa-mir-15b-3p ; hsa-mir-7-1-3p ; hsa-mir-125b-5p ; hsa-mir-141-3p ; hsa-mir-214-5p ; hsa-mir-448 ; hsa-mir-217
Nearest miRNA
hsa-mir-10393/Upstream/113088; hsa-mir-1302-10/Downstream/3062869;
Nearest cancer related gene
IGF1R(OG, No orient, 0)
Upstream sequence
gcatttttaatatgtgtatggaggaagttcgtcaagatgggtgccatctggcagtggagtagcacttcctggaaagtaatgagctccctTGGACTTTGTT
Downstream sequence
ttttgagacagggtctcactgtatcacccaggctggagtgcaatggcataatcatagctcactgtaacctggaactcctagtctcaaacaatccttctgc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate