Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene168980839168834132168913371168786539168865514168849691168849840168851911168852060168856751168856900168883689
Basic Information
VIS ID
TVIS20000169
Fusion event
HPV-SPC25 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
169740199/168883689 (Hg38)
End
169740199/168883689 (Hg38)
Location type
Intronic
Target gene
SPC25
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-26b-5p ; hsa-mir-3674 ; hsa-mir-135b-3p ; hsa-mir-7156-3p ; hsa-mir-6516-3p ; hsa-mir-1206 ; hsa-mir-8065 ; hsa-mir-1255b-5p ; hsa-mir-1255a ; hsa-mir-3121-5p ; hsa-mir-3914 ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p ; hsa-mir-8054 ; hsa-mir-548l ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-5582-3p ; hsa-mir-548a-5p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-8084
Nearest miRNA
hsa-mir-128-1/Upstream/300671; hsa-mir-10b/Downstream/6283944;
Nearest TSS
ENST00000437798/Upstream/24580; ENST00000429379/Downstream/5604;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/426577, chr2-CpG: 22/Downstream/6520
Upstream sequence
GTGGAGAACCAAAGTTAACTCTTTTTTTTCCTTTAAGGAGAAATGAACCATATTTTTATTACTATAACCAATATCAAATTTATATTCAAAACCATCACCA
Downstream sequence
gtttttattatAACATTTGAAGAACTGTGTGATTTGTGGCCAATACAAATATAGGAGTCCTCGATGCTGTATGACCAtttttttttcttttttttttttt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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