Basic Information
VIS ID
TVIS20000180
Fusion event
HPV-CASC21 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
128275951/127263706 (Hg38)
End
128275951/127263706 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
CASC21
Nearest miRNA
hsa-mir-12123/Upstream/2441648; hsa-mir-10400/Downstream/532256;
Nearest TSS
ENST00000518652/Upstream/19069; ENST00000642795/Downstream/29106;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/705181, chr8-CpG: 29/Downstream/51936
Upstream sequence
CCTTAATGTCTTTTTCTTGATCCTTCTTTTGAGTCCTAAGTACCGCCATTACAGCTTCAAATTGGCACGTCATATAGGCGAATTTCAAAGGGAGATGCAA
Downstream sequence
TTTTCCTCAGGCAATTATTAGAACCACTGTAAACAACTCAGATTTTTGGAGAAAACAGTGAAGAAGCTTTAGATCAGCAAAATAGTCGACACATGGTCCA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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