Basic Information
VIS ID
TVIS20000184
Fusion event
HPV-chr11:q14.3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1;EF202167.1
Host Sequence
Chromosome
chr11
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
91949471/92216305 (Hg38)
End
91949471/92216305 (Hg38)
Nearest miRNA
hsa-mir-10392/Upstream/1347103; hsa-let-7a-2/Downstream/1517369;
Nearest TSS
ENST00000527297/Upstream/412950; ENST00000528921/Downstream/135791;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1993115, chr11-CpG: 204/Downstream/8164
Nearby gene
FAT3(+8331) ;
Upstream sequence
ACGAACAGCAGGGCTATATCTTGCAAGTCTATACCTTGCAAAAGCAACACCAAACTAGAGAGAAGGGAGAATATGATCACAACAGATCAGTCTAAGTAAG
Downstream sequence
AGTGGAGGGAATGAATCCTTAGGAAAGGTCCACACAGATCCACTCACAGAGCCAAACCCCGTTTTGAAAACCTGAATGAGGTATTGACATATATCTTGGA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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