Basic Information
VIS ID
TVIS20000185
Fusion event
HPV-DLEU1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1;EF202167.1
Host Sequence
Chromosome
chr13
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
50793472/50219336 (Hg38)
End
50793472/50219336 (Hg38)
Location type
Intronic
Target gene
DLEU1
miRNAs that regulate target gene
hsa-mir-640 ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-622 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4713-5p ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-2116-3p ; hsa-mir-4736 ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-488-5p ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-3910 ; hsa-mir-3714
Nearest miRNA
hsa-mir-15a/Upstream/170135; hsa-mir-1267/Downstream/1129231;
Nearest TSS
ENST00000623511/Upstream/93616; ENST00000413510/Downstream/308113;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/85453, chr13-CpG: 62/Downstream/623899
Nearest cancer related gene
DLEU1(TSG, No orient, 0)
Upstream sequence
ctgtaatcccagcactttgggaggctgaggagggcagattacgagatcaagagttcgagaccagcctgaccaacatagtgaaatcccgtctctactaaaa
Downstream sequence
atacaaaaattagctgggtgtagtggcacacgcctgtaatcccagctactcgggaggctggggaaggagaatcacttgaacctgggaggcggacgttgca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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