Basic Information
VIS ID
TVIS20000186
Fusion event
HPV-chr21:q22.11 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1;EF202167.1
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
End
33996659/32624349 (Hg38)
Nearest miRNA
hsa-let-7c/Upstream/2248971; hsa-mir-3197/Downstream/926313;
Nearby gene
OR7E23P(-2305) ; SYNJ1(+4410) ;
Upstream sequence
TTACATATTTTACAGGGTCTCaatataatttttaataatattGAGAAATGTAGAAAATCGTTGCATAAGAACCCATGTACTGACCATCCAGTTTTGTTTA
Downstream sequence
AATATGTAGGTTAGTAATCATCTAGTGATTATTAAAATCACCACAGATCAAGCCTGTGCAGTATCTTTAAATTTGTCAGCCCTGGTATTCGTTGTCCTCA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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