Basic Information
VIS ID
TVIS20000191
Fusion event
HPV-chr6:p22.2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Squamous-cell carcinoma (SCC)
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1;EF202167.1
Host Sequence
Chromosome
chr6
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
25222023/25221795 (Hg38)
End
25222023/25221795 (Hg38)
Fragile sites / regions
FRA6C
Nearest miRNA
hsa-mir-3691/Upstream/6649915; hsa-mir-10398/Downstream/1925831;
Nearest TSS
ENST00000381078/Upstream/164722; ENST00000461945/Downstream/57283;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/81777, chr6-CpG: 76/Downstream/57108
Nearby gene
LOC100533655(-627) ;
Upstream sequence
TTTCAAGTTTTGACTTTTTAGTTTAAACCTAGAAAAAAGATAAACCTGTTGAATTTCTGTTCATGACTTGCAAAAATGGCATGCAGAAGAATAAGGAAAA
Downstream sequence
TCAATGTTTCCCTTCTTCACTGTTAATGTAAATGACTCACAATTTTTTTTAACCTATAACAGTATAGGTAAGTTAAGTCTCTTATTTCTTATATGATTAT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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