Basic Information
VIS ID
TVIS20000202
Fusion event
HPV-TRIM49C integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr11
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
89781502/90048334 (Hg38)
End
89781502/90048334 (Hg38)
Location type
Intronic
Target gene
TRIM49C
miRNAs that regulate target gene
hsa-mir-500a-3p
Nearest miRNA
hsa-mir-10392/Upstream/1871741; hsa-let-7a-2/Downstream/507440;
Nearest TSS
ENST00000527297/Upstream/17228; ENST00000530464/Downstream/37616;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/67701, chr11-CpG: 88/Downstream/3401
Upstream sequence
tgcagtgagctgaaatcactccactgcactccagcctgggcgacaaacaagactccgtctcgaaaaaaaaaaaaaaaaaaaaGGAGAACACTGTTTAGTA
Downstream sequence
AAATTAGTGTATTTAGACATATTGAGGCATTAGGCGATCTGATCAATGATAGTTTCCTTATGCTAAGAGCTGAAAGGTGTCATACACTAGTTGAAGAAAC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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