Basic Information
VIS ID
TVIS20000203
Fusion event
HPV-C12orf42 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
103812211/103418433 (Hg38)
End
103812211/103418433 (Hg38)
Location type
Intronic
Target gene
C12orf42
Nearest miRNA
hsa-let-7i/Upstream/3228484; hsa-mir-1178/Downstream/511992;
Nearest TSS
ENST00000382841/Upstream/148580; ENST00000551174/Downstream/23158;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/115793, chr12-CpG: 73/Downstream/77025
Upstream sequence
ctcacacctgtaatcccggcattttgggaggccaaggcaggcagatcacttgagatcgggagtttgagaccagactagtcgacatggtgaaaccccatct
Downstream sequence
GCATCCTCACATCATTTCTTTATTCATTAACACAATGATAATTATGAATGATAATATTGGGGGTCAATTTAGCTCAAGTGGGGCTGGGGCCTGGAAAGTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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