Basic Information
VIS ID
TVIS20000212
Fusion event
HPV-COX7B2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr4
Cytoband
p12
Reference genome
GRCh37/hg19
Start
46842892/46840875 (Hg38)
End
46842892/46840875 (Hg38)
Location type
Intronic
Target gene
COX7B2
Nearest miRNA
hsa-mir-12113/Upstream/6338756; hsa-mir-1243/Downstream/811794;
Nearest TSS
ENST00000502981/Upstream/365645; ENST00000381582/Downstream/35885;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/450320, chr4-CpG: 61/Downstream/152236
Upstream sequence
AGTTTAATTCTGACTTTATCCCTGTCACTATAACCATAAAAGAGAATCCCTGGCCTGGTTCCACCACACCCTGCCTCAATCCCAGCCCTGGCGAACATAC
Downstream sequence
AAAATAAAAGTAGAGCTGGGTTTTGAAACAAAAATAAAAGGACTCATTAAATGAAGAAGTACAGAAGGCTGTCACTGACATACGGAGTTGGTGCATAAAG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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