Basic Information
VIS ID
TVIS20000220
Fusion event
HPV-NKRF integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chrX
Cytoband
q24
Reference genome
GRCh37/hg19
Start
118726269/119592306 (Hg38)
End
118726269/119592306 (Hg38)
Location type
Intronic
Target gene
NKRF
miRNAs that regulate target gene
hsa-mir-301a-3p ; hsa-mir-374b-5p ; hsa-mir-340-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-326 ; hsa-mir-222-3p ; hsa-mir-6516-5p ; hsa-mir-1273e ; hsa-mir-455-3p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6499-3p ; hsa-mir-4785 ; hsa-mir-7854-3p ; hsa-mir-493-3p ; hsa-mir-6840-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-3174 ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-7977 ; hsa-mir-3162-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-383-3p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6760-5p ; hsa-mir-550a-5p ; hsa-mir-550a-3-5p ; hsa-mir-1271-3p ; hsa-mir-1268b ; hsa-mir-1268a ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-3656 ; hsa-mir-5690 ; hsa-mir-890
Nearest miRNA
hsa-let-7f-2/Upstream/1205835; hsa-mir-105-1/Downstream/54432;
Nearest TSS
ENST00000429181/Upstream/997; ENST00000343905/Downstream/844;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/17233, chrX-CpG: 83/Downstream/13301
Upstream sequence
AGAACAAGAATGTTGGATGAAACTCTTTTTTTGGGATCCCTCACTTTATGAAATTATCACATGTATAAAAGAGTAAAATTAAAATTCAAAGATTTGACAT
Downstream sequence
TATACCACACTCATATCATTTTTTTAAAGCCATGTTGTTTCTTCAAATCCCACCTTTCAGAAACAAGTATACTCACCATCACATGTTGAGAGGTGGCGTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate