Basic Information
VIS ID
TVIS20000236
Fusion event
HPV-IL1RAPL2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1;HQ537751.1
Host Sequence
Chromosome
chrX
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
104768979/105524986 (Hg38)
End
104768979/105524986 (Hg38)
Location type
Intronic
Target gene
IL1RAPL2
Nearest miRNA
hsa-let-7f-2/Upstream/10461760; hsa-mir-105-1/Downstream/1114828;
Nearest TSS
ENST00000429181/Upstream/304312; ENST00000485671/Downstream/192380;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/957624, chrX-CpG: 62/Downstream/297355
Upstream sequence
acaccacagagtactgtttagccataaaaaaaagaatgagattcagtcatttgcaacaacacggatagaaccgaaggtccttatgttaagtgaaataagc
Downstream sequence
TTTTCCTTGTAATTAGTTTATTTTTTTCCAAATAAACATTCTAGGATATTTTCTTGTTGCTGCTAGTTTGGGTTCACATTGTGACCCACTTGATACAAGG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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