Basic Information
VIS ID
TVIS20000251
Fusion event
HPV-FAM104A integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1;HQ537687.1
Host Sequence
Chromosome
chr17
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
71220975/73224836 (Hg38)
End
71220975/73224836 (Hg38)
Location type
Intronic
Target gene
FAM104A
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-34a-5p ; hsa-mir-196a-5p ; hsa-let-7d-5p ; hsa-mir-18a-5p ; hsa-mir-34c-5p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-548au-3p ; hsa-mir-218-5p ; hsa-mir-4646-3p ; hsa-mir-4433b-5p ; hsa-mir-513b-5p ; hsa-mir-4433a-5p ; hsa-mir-186-3p ; hsa-mir-500b-5p ; hsa-mir-362-5p ; hsa-mir-500a-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-4282 ; hsa-mir-3606-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-4276 ; hsa-mir-4775 ; hsa-mir-6761-5p ; hsa-mir-205-3p ; hsa-mir-98-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7i-5p ; hsa-let-7b-5p ; hsa-let-7e-5p ; hsa-let-7c-5p ; hsa-let-7a-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-mir-196b-5p ; hsa-mir-148a-3p ; hsa-mir-148b-3p ; hsa-mir-152-3p ; hsa-mir-4668-5p ; hsa-mir-3613-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-6796-3p ; hsa-mir-30e-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30a-5p
Nearest miRNA
hsa-mir-10226/Upstream/4125180; hsa-mir-1250/Downstream/1523777;
Nearest TSS
ENST00000595228/Upstream/18095; ENST00000585109/Downstream/2864;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/31517, chr17-CpG: 87/Downstream/7085
Upstream sequence
TTTTAaataatagaattggaaacatttacaaaccaataacattgaaaaccgacatgaagttgctaaactcctagagaactataaaatgagaaaaacaaaa
Downstream sequence
cagcacaggacaggacaggacaggacagcacaggacaggacagcacagcacaggacaggacaggacaggacaggacaggacaggacaggacaggacagca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate