Basic Information
VIS ID
TVIS20000286
Fusion event
HPV-EEA1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
93284114/92890338 (Hg38)
End
93284114/92890338 (Hg38)
Location type
Intronic
Target gene
EEA1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-124-3p ; hsa-mir-192-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-574-5p ; hsa-mir-4455 ; hsa-mir-5682 ; hsa-mir-585-5p ; hsa-mir-3152-3p ; hsa-mir-6867-5p ; hsa-mir-3650 ; hsa-mir-509-3p ; hsa-mir-101-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-20b-5p
Nearest miRNA
hsa-let-7i/Upstream/6145189; hsa-mir-1178/Downstream/1671451;
Nearest TSS
ENST00000382841/Upstream/69239; ENST00000549914/Downstream/38924;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/743781, chr12-CpG: 133/Downstream/38228
Upstream sequence
GAGTGTCCTAATCTCTTGTGATATGGCTGTACCTACAAGGCCAATTTTCAAGGAGACTCAGTACTCTTGGGATAAGGGTGGTCAACCTTTTCTGAATGAG
Downstream sequence
tcacgattatgtattcagtaaatgggactccatgttcagtgtgctataaaaaaattcctaatttcatccaattctaaatataatctttgaccattgattt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate