Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene130836143130396137130716281130609162130612608130571050130574095130615389130618138130583264130585056130612670130614358130575888130577136130580660130581854130585248130586388130600089130601070130592657130593467130608242130609038130567129130567922130574182130574969130591476130592262130578146130578873130582279130582908130587845130588445130589916130590005130616140
Basic Information
VIS ID
TVIS20000288
Fusion event
HPV-RIMBP2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
131100685/130616140 (Hg38)
End
131100685/130616140 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
RIMBP2
miRNAs that regulate target gene
hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4286 ; hsa-mir-330-3p
Nearest miRNA
hsa-let-7i/Upstream/2321962; hsa-mir-6763/Downstream/1965857;
Nearest TSS
ENST00000382841/Upstream/98223; ENST00000443685/Downstream/17721;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/146856, chr12-CpG: 20/Downstream/25163
Upstream sequence
gggcggggtggcgcatgcctgtaatcccagctacttgggaggctgaggcaggagaatcgcttgaacccaggaggtggaggttgcggtgagctgagattga
Downstream sequence
accattgccctccagcctgggcaacaagagcaaaactccatctcaaaaaaaaaaaagaagtaagtaatattcagttatggatatatggatatataaacta
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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