Basic Information
VIS ID
TVIS20000289
Fusion event
HPV-TRA integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
22463510/21995271 (Hg38)
End
22463510/21995271 (Hg38)
Location type
Intronic
Target gene
TRA
Nearest miRNA
hsa-mir-6717/Upstream/971885; hsa-mir-1185-1/Downstream/961679;
Nearest TSS
ENST00000550708/Upstream/4775; ENST00000390445/Downstream/2268;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/483714, chr14-CpG: 40/Downstream/593744
Upstream sequence
tagtagctgggactacaggtgcgtgccaccacgctcagctaatttttgtatttttttgtagaggtacagtttcctcatgttgcccaggctggtttcaaac
Downstream sequence
aggacattgttgagtaaaatctttttctcttgccagtgtggtggtaatgattatgtacaatgactactagaatattttgggttcatttattttacctgtg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate