Basic Information
VIS ID
TVIS20000290
Fusion event
HPV-LRR1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr14
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
50074236/49607518 (Hg38)
End
50074236/49607518 (Hg38)
Location type
Intronic
Target gene
LRR1
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-423-3p
Nearest miRNA
hsa-mir-208a/Upstream/1846414; hsa-mir-1185-1/Downstream/358881;
Nearest TSS
ENST00000550708/Upstream/7106; ENST00000305386/Downstream/13167;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/7371, chr14-CpG: 136/Downstream/12719
Upstream sequence
gatgaactttatgcatacgtcctatgtcatcacacagaatatttaaacggtgtactctcaagggtcaagatttaatttaaaaaattttgcttctacatct
Downstream sequence
TAAAACTAAAATGGTTATCACATCCAAAAAAGACTATCCTCTAAGTAAGAATTTTCCATATTCCTTGGAACATCTTCAGACTTCTTACTGTGGGCTTGTC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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