Basic Information
VIS ID
TVIS20000297
Fusion event
HPV-CCDC33 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr15
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
74582046/74289705 (Hg38)
End
74582046/74289705 (Hg38)
Location type
Intronic
Target gene
CCDC33
miRNAs that regulate target gene
hsa-mir-580-3p ; hsa-mir-4735-5p ; hsa-mir-6822-3p
Nearest miRNA
hsa-mir-10393/Upstream/989726; hsa-mir-11181/Downstream/121652;
Nearest TSS
ENST00000557528/Upstream/22987; ENST00000563951/Downstream/6108;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/43962, chr15-CpG: 66/Downstream/75992
Upstream sequence
TACAGAAGAGCCTCATGTCAAGATTCATTTCAATCAGGGATTAAATCTAGTCATTCATTCACTCATTCCACAAATTTAAATCAAAACACTAAACTAGCTT
Downstream sequence
gaacttgggagattgagtctacagtgagctgagatggtgccactacaccccagcctgggcaacagagtgagaacctttgtctATTTATTTTTTTAAATGC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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