Basic Information
VIS ID
TVIS20000298
Fusion event
HPV-ARHGAP17 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
24984416/24973095 (Hg38)
End
24984416/24973095 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA16E
Target gene
ARHGAP17
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-324-3p ; hsa-mir-320a ; hsa-mir-25-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1225/Upstream/769864; hsa-mir-11401/Downstream/1052142;
Nearest TSS
ENST00000527434/Upstream/13114; ENST00000571219/Downstream/4361;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/242614, chr16-CpG: 66/Downstream/41651
Upstream sequence
tcagtgtgcccaaccaaaaatttctggattctttttgtaaagaagaaggggagaattgatgttaataggaaactaatggtctcCTTCTGTGTGGGGAGCA
Downstream sequence
aagtgctgagattacaggagtgcagcaccatgcctggccAGGGATGAATTTTAAATGCTCTAAAGACTTAATTTGTAAAATGCATGCCAATCGCACAAAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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