Basic Information
VIS ID
TVIS20000303
Fusion event
HPV-ITFG1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
47403056/47369145 (Hg38)
End
47403056/47369145 (Hg38)
Location type
Intronic
Target gene
ITFG1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-23b-3p
Nearest miRNA
hsa-mir-1225/Upstream/13205472; hsa-mir-11401/Downstream/2923471;
Nearest TSS
ENST00000527434/Upstream/56870; ENST00000566721/Downstream/27075;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/330886, chr16-CpG: 48/Downstream/91641
Upstream sequence
ctctcATTTGCACTCTATTTTCCTCTCTCTTTGTCGTCCTGTTTCCCTTTCTTCTCCCAAGTTCTCCTGCTCCTGCCACAAGTGGGGCTGGGCCACAACA
Downstream sequence
GTGCAGCATAACTACGCTCATTTTCAAAGATGAAGCTGCTCGGTAGCTATTAATGAGGCAGGAGAAACATGATCAATACTGTTTTTCATTTTGAACATAT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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