Basic Information
VIS ID
TVIS20000310
Fusion event
HPV-CDH13 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr16
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
83814708/83781103 (Hg38)
End
83814708/83781103 (Hg38)
Location type
Intronic
Target gene
CDH13
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-181a-5p ; hsa-mir-4464 ; hsa-mir-4307 ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-31-3p ; hsa-mir-367-5p ; hsa-mir-1266-3p
Nearest miRNA
hsa-mir-1225/Upstream/272695; hsa-mir-11401/Downstream/1426693;
Nearest TSS
ENST00000527434/Upstream/8167; ENST00000567382/Downstream/22425;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/1152895, chr16-CpG: 67/Downstream/26704
Nearest cancer related gene
CDH13(TSG, No orient, 0)
Upstream sequence
atttaaccaagaaagtacaagacttatgcaccgaaaactacaacacacttttgaaagcaatcaaagacgacctaaataaatagaaacacatctcatatta
Downstream sequence
TTCTCCTTTATAAAACTTGCAAGCAATGTCTCCTCCCACAAGTCCTTCCACATAGGCAGGTGGAATTCAAAACTTAACCCAACTTCTATCACTTGCCTTA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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