Basic Information
VIS ID
TVIS20000338
Fusion event
HPV-MACROD2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
14623500/14642854 (Hg38)
End
14623500/14642854 (Hg38)
Location type
Intronic
Target gene
MACROD2
miRNAs that regulate target gene
hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-4469 ; hsa-mir-486-5p ; hsa-mir-660-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-618 ; hsa-mir-502-5p ; hsa-mir-4786-3p ; hsa-mir-1915-5p ; hsa-mir-6841-3p ; hsa-mir-153-5p ; hsa-mir-6808-3p ; hsa-mir-7973 ; hsa-mir-486-3p ; hsa-mir-4252 ; hsa-mir-4725-5p ; hsa-mir-6852-5p ; hsa-mir-6791-5p ; hsa-mir-4292 ; hsa-mir-504-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/3993159; hsa-mir-1-1/Downstream/3827761;
Nearest TSS
ENST00000382410/Upstream/119456; ENST00000486914/Downstream/286632;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/646432, chr20-CpG: 50/Downstream/1930337
Upstream sequence
aggactgggccacaaagtgctcaaatcctgaccttcccgatggcttgcaggaaagtgtagtgcaggggtaaatttcaggaaaggagaagctacaggcaaa
Downstream sequence
acagagacacaaagtaagcatatactgttggaaaaagtggtgctgatagtcttgctcaacacatggttgccacaaaccttcagtttgtaaaaaaaatgca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate