Basic Information
VIS ID
TVIS20000365
Fusion event
HPV-MCCC1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr3
Cytoband
q27.1
Reference genome
GRCh37/hg19
Start
182759961/183042173 (Hg38)
End
182759961/183042173 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
MCCC1
Nearest miRNA
hsa-let-7g/Upstream/6527022; hsa-mir-1224/Downstream/844627;
Nearest TSS
ENST00000440867/Upstream/4818; ENST00000477699/Downstream/52434;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/61230, chr3-CpG: 40/Downstream/22213
Upstream sequence
TGTGAACAAAGAGAGAACAAGAGAGATTAATTTCTTTTTAATCCTTCCTTTCTAGCAAGGGCTTGACCTCAGGCTTTGGCCTGTTTCAGCTTCTCCCCAG
Downstream sequence
AAAAAGTGTAGCTGACATTGTCATCCTACGCTGTAATCTTCACCAGTAAGTGGGTGATAAAGCAAAACAGAAAGGGGAAAATGATGGTTTTTCAATTTTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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