Basic Information
VIS ID
TVIS20000374
Fusion event
HPV-UBE2D3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
End
103785465/102864308 (Hg38)
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-101-3p ; hsa-mir-98-5p ; hsa-let-7b-5p ; hsa-mir-877-3p ; hsa-mir-423-5p ; hsa-mir-218-5p ; hsa-mir-136-5p ; hsa-mir-6126 ; hsa-mir-6864-5p ; hsa-mir-920 ; hsa-mir-6726-5p ; hsa-mir-5591-5p ; hsa-mir-4300 ; hsa-mir-3934-3p ; hsa-mir-3670 ; hsa-mir-539-5p ; hsa-mir-493-3p ; hsa-mir-4635 ; hsa-mir-3664-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-4453 ; hsa-mir-4538 ; hsa-mir-6854-5p ; hsa-mir-5003-3p ; hsa-mir-6833-5p ; hsa-mir-7847-3p ; hsa-mir-3190-3p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-4795-5p ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-4519 ; hsa-mir-301b-3p ; hsa-mir-130b-3p ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-454-3p ; hsa-mir-130a-3p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-152-3p ; hsa-mir-148b-3p ; hsa-mir-148a-3p ; hsa-mir-188-3p ; hsa-mir-195-3p ; hsa-mir-4733-5p ; hsa-mir-16-2-3p ; hsa-mir-577 ; hsa-mir-888-5p ; hsa-mir-376c-3p ; hsa-mir-421 ; hsa-mir-7159-5p ; hsa-mir-676-5p ; hsa-mir-505-3p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-7162-3p ; hsa-mir-544b ; hsa-mir-6849-3p ; hsa-mir-6771-3p ; hsa-mir-1245b-3p ; hsa-mir-1249-5p ; hsa-mir-1257 ; hsa-mir-1321 ; hsa-mir-1343-5p ; hsa-mir-30a-5p ; hsa-mir-30b-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-3607-5p ; hsa-mir-3613-3p ; hsa-mir-4330 ; hsa-mir-4419a ; hsa-mir-4510 ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-4790-3p ; hsa-mir-4802-5p ; hsa-mir-551b-5p ; hsa-mir-6081 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6515-5p ; hsa-mir-6783-5p ; hsa-mir-6797-5p ; hsa-mir-6799-5p ; hsa-mir-6824-5p ; hsa-mir-939-5p ; hsa-mir-942-5p
Nearest miRNA
hsa-mir-12113/Upstream/1533894; hsa-mir-1243/Downstream/6624390;
Nearest CpG islands
Upstream sequence
aaatatttgtctgttgatttgtagtaattctttacatcttttgaaagtgaatttcttatcggttataagtcacatatgaagtccatcagggcttttcttt
Downstream sequence
attaaatgccctttcttgaccaaataaaaaattggcaaacctatcttgacttcccaatttATCCAGGAATGGGCTGACAGAGCAGAAAAAGACAGGGTTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate