Basic Information
VIS ID
TVIS20000380
Fusion event
HPV-ZNF608 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr5
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
124050118/124714425 (Hg38)
End
124050118/124714425 (Hg38)
Location type
Intronic
Target gene
ZNF608
miRNAs that regulate target gene
hsa-mir-142-3p ; hsa-mir-331-3p ; hsa-mir-4668-5p ; hsa-mir-218-5p ; hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-5011-5p ; hsa-mir-410-3p ; hsa-mir-5683 ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-4272 ; hsa-mir-5697 ; hsa-mir-1183 ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-6083 ; hsa-mir-3163 ; hsa-mir-5582-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-21-3p
Nearest miRNA
hsa-mir-10397/Upstream/5559709; hsa-mir-103a-1/Downstream/4383263;
Nearest TSS
ENST00000502646/Upstream/6598; ENST00000511091/Downstream/29942;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/62370, chr5-CpG: 30/Downstream/1708930
Upstream sequence
tatagacgaacgaattcaaagtaatagaaaacagaaaaaataatagatgaatttaaATAAGGTTACatcctactaaatatttaaacaggaaataatacta
Downstream sequence
AGGATGACAGGTCAATGTCACACATCACATGTCTCACTAATGCTTTTGAACTGGGTaatatagtgtaataaataggagtgtggtctctgtgcttcaatct
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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