Basic Information
VIS ID
TVIS20000396
Fusion event
HPV-APTR integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
77313207/77683890 (Hg38)
End
77313207/77683890 (Hg38)
Location type
Intronic
Target gene
APTR
Nearest miRNA
hsa-mir-10525/Upstream/1768621; hsa-mir-10399/Downstream/14520125;
Nearest TSS
ENST00000635602/Upstream/46918; ENST00000462800/Downstream/12363;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/145870, chr7-CpG: 104/Downstream/12203
Upstream sequence
gaaaaaaacaaacaatctcatcaaaaagtgggccgaggacacgactacaccatcctcaaaaaaagatatacaagtggccaacaaacatatgaaaaaatgc
Downstream sequence
gtactataataacaattacacacattgtaactcctacacaatttgaaattttcaagttaagacaaaggtaactatatatagaagcagtatgttttctgaa
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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