Basic Information
VIS ID
TVIS20000409
Fusion event
HPV-NSMCE2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;HQ537687.1
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
GRCh37/hg19
Start
126370304/125358062 (Hg38)
End
126370304/125358062 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA8C ; FRA8E
Target gene
NSMCE2
miRNAs that regulate target gene
hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-4740-3p ; hsa-mir-764 ; hsa-mir-6504-3p ; hsa-mir-3159 ; hsa-mir-552-3p ; hsa-mir-1303 ; hsa-mir-3188 ; hsa-mir-6866-5p ; hsa-mir-877-5p
Nearest miRNA
hsa-mir-12123/Upstream/536004; hsa-mir-10400/Downstream/2437900;
Nearest TSS
ENST00000518652/Upstream/6646; ENST00000521460/Downstream/4964;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/266182, chr8-CpG: 216/Downstream/71167
Upstream sequence
TACATTCCTTTTAGGACAACAGCTGTACAATTATTCTCTTGCTACATTTCTCTTGTAGGTAGGAATTTTTAATATGATTAATCACACATTCATTTTTTTA
Downstream sequence
tggctcatgcctgtaatcctagcactttgggaagccgaggtgggcagatcacctgaggtcaggagttcaagaccagcctggccaacatggtgaaacccca
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate