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Viral Integration Site DataBase
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TVIS20000421
Proximate region of VIS (GRCh38)
VIS
Enhancer
Enhancer/Promoter
Promoter
Gene
48411924
48314637
48379294
48311642
48317870
48342690
48347058
48324122
48327684
48319012
48322399
48352126
48354599
48349522
48351302
48356202
48357868
48333419
48335031
48339720
48341314
48328401
48329800
48330167
48331314
48332259
48332691
48318188
48318600
48341601
48342000
48331601
48331800
48339401
48339600
48361783
Basic Information
VIS ID
TVIS20000421
Fusion event
HPV-FOXN2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
48588922/48361783 (Hg38)
End
48588922/48361783 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
FOXN2
miRNAs that regulate target gene
hsa-mir-186-5p
;
hsa-mir-218-5p
;
hsa-mir-32-5p
;
hsa-mir-188-5p
;
hsa-mir-183-5p
;
hsa-mir-100-5p
;
hsa-mir-25-3p
;
hsa-mir-29a-5p
;
hsa-mir-92a-3p
;
hsa-mir-363-3p
;
hsa-mir-367-3p
;
hsa-mir-92b-3p
;
hsa-mir-548j-3p
;
hsa-mir-1277-5p
;
hsa-mir-548x-3p
;
hsa-mir-3613-3p
;
hsa-mir-548ae-3p
;
hsa-mir-548ah-3p
;
hsa-mir-548aj-3p
;
hsa-mir-548am-3p
;
hsa-mir-548aq-3p
;
hsa-mir-5582-3p
;
hsa-mir-559
;
hsa-mir-548b-5p
;
hsa-mir-548a-5p
;
hsa-mir-548c-5p
;
hsa-mir-548d-5p
;
hsa-mir-2113
;
hsa-mir-548j-5p
;
hsa-mir-548k
;
hsa-mir-548l
;
hsa-mir-548h-5p
;
hsa-mir-548i
;
hsa-mir-548w
;
hsa-mir-548y
;
hsa-mir-548o-5p
;
hsa-mir-548ab
;
hsa-mir-548ad-5p
;
hsa-mir-548ae-5p
;
hsa-mir-548ak
;
hsa-mir-548am-5p
;
hsa-mir-4724-5p
;
hsa-mir-548ap-5p
;
hsa-mir-548aq-5p
;
hsa-mir-548ar-5p
;
hsa-mir-548as-5p
;
hsa-mir-548au-5p
;
hsa-mir-548av-5p
;
hsa-mir-548ay-5p
;
hsa-mir-8054
;
hsa-mir-548bb-5p
;
hsa-mir-4495
;
hsa-mir-4662a-3p
;
hsa-mir-7109-3p
;
hsa-mir-3148
;
hsa-mir-6124
;
hsa-mir-5692a
;
hsa-mir-548n
;
hsa-mir-4427
;
hsa-mir-4680-3p
;
hsa-mir-5187-3p
;
hsa-mir-30a-5p
;
hsa-mir-30c-5p
;
hsa-mir-30d-5p
;
hsa-mir-30b-5p
;
hsa-mir-30e-5p
;
hsa-mir-6083
;
hsa-mir-651-5p
;
hsa-mir-3978
;
hsa-mir-27b-3p
;
hsa-mir-27a-3p
;
hsa-mir-5579-3p
;
hsa-mir-4791
;
hsa-mir-3201
;
hsa-mir-190b
;
hsa-mir-190a-5p
;
hsa-mir-4328
;
hsa-mir-570-3p
;
hsa-mir-3681-3p
;
hsa-mir-216a-3p
;
hsa-mir-128-3p
;
hsa-mir-4781-3p
;
hsa-mir-3074-3p
;
hsa-mir-590-5p
;
hsa-mir-21-5p
;
hsa-mir-6809-3p
;
hsa-mir-6833-3p
;
hsa-mir-4768-5p
;
hsa-mir-3191-5p
;
hsa-mir-4653-5p
;
hsa-mir-3921
;
hsa-mir-301b-5p
;
hsa-mir-301a-5p
;
hsa-mir-146a-3p
;
hsa-mir-5688
;
hsa-mir-380-3p
;
hsa-mir-411-3p
;
hsa-mir-379-3p
;
hsa-mir-497-3p
;
hsa-mir-3133
;
hsa-mir-496
Nearest miRNA
hsa-mir-1301/Upstream/984013; hsa-mir-10b/Downstream/697820;
Nearest TSS
ENST00000437798/Upstream/15566;
ENST00000421486/Downstream/78814;
Nearest CpG islands
None/Target,
chr2-CpG: 135/Upstream/46335
,
chr2-CpG: 60/Downstream/78637
Upstream sequence
catttttaggctcacagacaaactgagtgaaagacacagagcgttcccatatccccctgagccctccctagacacactcagcctcccccattatcagcat
Downstream sequence
AAAAAGAACTGTTGGTGTCTTTCCATGAATATAGAAAGTTTAATTTTATGTTTATTAATAAAATCAGGAACATACCTGTTTGCTATCACTACCAAGTGTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Sample Information
×
Sample name
T3472
Sample type
Tumor
Gender
Female
CpG Island Information
×
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