Basic Information
VIS ID
TVIS20000425
Fusion event
HPV-TEX2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr17
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
62336853/64259493 (Hg38)
End
62336853/64259493 (Hg38)
Location type
Intronic
Target gene
TEX2
miRNAs that regulate target gene
hsa-mir-32-5p ; hsa-mir-26b-5p ; hsa-mir-423-5p
Nearest miRNA
hsa-mir-10226/Upstream/1315181; hsa-mir-1250/Downstream/241281;
Nearest TSS
ENST00000595228/Upstream/3402; ENST00000617071/Downstream/3734;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/112729, chr17-CpG: 92/Downstream/2950
Upstream sequence
CTGAGCCTCAGTTCCTGGGCCCCTGGTCCCTGACACCCCAGAGCCTGCCTGGCCTCCGACCCTCAAGCCTCTTACCCTTTCTTTTCCTCAAGGCTCCTCT
Downstream sequence
TGAATAGGAAGACAAAGGGAGCTGTCTGTCCATGGCTCGTTAGCTCCTGAAGTTAATGTTTCTCACAGGGACAAGAGTCAGCCAAAGGATAGTGCTCTAG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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