Basic Information
VIS ID
TVIS20000432
Fusion event
HPV-PPIG integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
170469613/169613103 (Hg38)
End
170469613/169613103 (Hg38)
Location type
Intronic
Target gene
PPIG
miRNAs that regulate target gene
hsa-let-7e-5p ; hsa-mir-525-3p ; hsa-mir-510-3p ; hsa-mir-3161 ; hsa-mir-4738-3p ; hsa-mir-4310 ; hsa-mir-7157-5p ; hsa-mir-580-5p ; hsa-mir-5583-5p ; hsa-mir-6838-5p ; hsa-mir-3129-3p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-573 ; hsa-mir-3616-5p ; hsa-mir-340-5p ; hsa-mir-4795-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-454-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-6507-5p ; hsa-mir-186-5p ; hsa-mir-3133
Nearest miRNA
hsa-mir-128-1/Upstream/1030085; hsa-mir-10b/Downstream/5554530;
Nearest TSS
ENST00000437798/Upstream/9063; ENST00000466142/Downstream/17747;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/28272, chr2-CpG: 59/Downstream/81170
Upstream sequence
agttgaatctcaccacattccatcttccacagagttgccaaagttaaatttctaaaccaataaggtgatggaccttttaccattctccaaatccataaga
Downstream sequence
tgcaaataaagttatcagtgaagtgaggatcaactATATCTAAATGCAAATCATATATATGCATTGTGACTATAACATGTTATATGAATACACATAGTGT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate