Basic Information
VIS ID
TVIS20000441
Fusion event
HPV-OPCML integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
q25
Reference genome
GRCh37/hg19
Start
132380760/132510866 (Hg38)
End
132380760/132510866 (Hg38)
Location type
Intronic
Target gene
OPCML
miRNAs that regulate target gene
hsa-mir-3149 ; hsa-mir-297 ; hsa-mir-675-3p ; hsa-mir-3924 ; hsa-mir-8068 ; hsa-mir-190a-3p ; hsa-mir-567 ; hsa-mir-4307 ; hsa-mir-5011-5p
Nearest miRNA
hsa-let-7a-2/Upstream/1844063; hsa-mir-4697/Downstream/1387638;
Nearest TSS
ENST00000527297/Upstream/178376; ENST00000532272/Downstream/349911;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/599228, chr11-CpG: 33/Downstream/431901
Nearest cancer related gene
OPCML(TSG, No orient, 0)
Upstream sequence
CAAATCATTTGCCATTCTCCTCttttttttttttgagacagagtctcactctgtcaccttggctggcgtgcagtggcacaatcttagctcaatgcaacct
Downstream sequence
ccgcctcccgggttcaagtgattctcctgccttagcctcctgagtagctgggactacaggcatctgccactgcacctggctaatttttgtatttttagta
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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