Basic Information
VIS ID
TVIS20000450
Fusion event
HPV-PATZ1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
31725138/31329152 (Hg38)
End
31725138/31329152 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA22B
Target gene
PATZ1
miRNAs that regulate target gene
hsa-mir-100-5p ; hsa-mir-942-5p ; hsa-mir-7114-5p ; hsa-mir-4443 ; hsa-mir-516b-5p ; hsa-mir-3191-5p ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6089 ; hsa-mir-6824-3p ; hsa-mir-6764-3p ; hsa-mir-330-5p ; hsa-mir-326 ; hsa-mir-518c-5p ; hsa-mir-4636 ; hsa-mir-3680-5p ; hsa-mir-29b-3p ; hsa-mir-1285-3p ; hsa-mir-3187-5p ; hsa-mir-3620-3p ; hsa-mir-3914 ; hsa-mir-4731-5p ; hsa-mir-5189-5p ; hsa-mir-5589-5p ; hsa-mir-612 ; hsa-mir-621 ; hsa-mir-6721-5p ; hsa-mir-6776-3p ; hsa-mir-6860 ; hsa-mir-873-5p
Nearest miRNA
hsa-mir-1286/Upstream/169033; hsa-let-7a-3/Downstream/292315;
Nearest TSS
ENST00000624155/Upstream/36618; ENST00000451161/Downstream/6197;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/37767, chr22-CpG: 213/Downstream/15907
Nearest cancer related gene
PATZ1(OG, No orient, 0)
Upstream sequence
CTGGCTCAAAAATGGCTGCAACCACATGAGCCATGTGACTCAGGATGGAGGGTGGCACTGTCCACAAATCGGCTTCTCTGCAGAGCCCACTCTGCAAGGC
Downstream sequence
TGCGGTGAGGGGCTGAGGCTGGCTGCCTGGTGGGATGGCCTGAGATCCTGCTCCTGCTAGGGCCAGAGGCCAACTGCCTCTAGGGTTGCTTGGTGCCTCA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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