Basic Information
VIS ID
TVIS20000458
Fusion event
HPV-GNPAT integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1;HQ537751.1
Host Sequence
Chromosome
chr1
Cytoband
q42.2
Reference genome
GRCh37/hg19
Start
231382405/231246659 (Hg38)
End
231382405/231246659 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
GNPAT
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-331-3p
Nearest miRNA
hsa-mir-101-1/Upstream/226735; hsa-mir-1537/Downstream/2377493;
Nearest TSS
ENST00000473358/Upstream/5443; ENST00000492459/Downstream/19475;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/5162, chr1-CpG: 101/Downstream/90860
Upstream sequence
GCTGGGATGGAGGGCTGAATTCCTCAcaggcactgtgtggagcgcttcccacacctctccacctccctgtaccactggatccacacaacaacactgaatc
Downstream sequence
aggcagtattgcccttctttgcagaagagccaacagctgttctgagaggtcaggtgacttgcctaaggtcactaggttctaaagtcatggagccaggatc
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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