Basic Information
VIS ID
TVIS20000489
Fusion event
HPV-CCDC146 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1;HQ537751.1
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
76841805/77212488 (Hg38)
End
76841805/77212488 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
CCDC146
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10525/Upstream/1297219; hsa-mir-10399/Downstream/14991527;
Nearest TSS
ENST00000635602/Upstream/12640; ENST00000461882/Downstream/29858;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/90411, chr7-CpG: 111/Downstream/203035
Upstream sequence
ccctcctcagcctcccaaagtgctgggattacaggtgtgaactaccacgcctggccTAGCATCTTTCTGTTTTCTTTTTATTTTTTCCCAAGTGAATGTA
Downstream sequence
cgtgcacctgtagtcccagctacttcagaggctgaggcaagagaatggcatgaacccaggaggcggagcatgcagtgagccgagatcacgccactgcact
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate