Basic Information
VIS ID
TVIS20000490
Fusion event
HPV-CDK14 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1;HQ537751.1
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
90325532/90696218 (Hg38)
End
90325532/90696218 (Hg38)
Location type
Intronic
Target gene
CDK14
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-376c-3p ; hsa-mir-493-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6785-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4533 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6783-5p ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-4428
Nearest miRNA
hsa-mir-10525/Upstream/14780949; hsa-mir-10399/Downstream/1507797;
Nearest TSS
ENST00000635602/Upstream/98865; ENST00000496279/Downstream/13033;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/99168, chr7-CpG: 255/Downstream/568060
Nearest cancer related gene
CDK14(OG, No orient, 0)
Upstream sequence
acgcctggccTAGCATCTTTCTGTTTTCTTTTTATTTTTTCCCAAGTGAATGTAAAAgcatcttagttttttcactaaatatataaatggggagcatagt
Downstream sequence
gaaatttgagtgatgtaaaggtaggctcatattgagatgggggaatatcggaaggaggagcaaggtttttgagaggttatggaatcaggaatttgatttg
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate