Basic Information
VIS ID
TVIS20000494
Fusion event
HPV-AIG1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Reference genome
NC_001526.2;AY262282.1
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
143631847/143310710 (Hg38)
End
143631847/143310710 (Hg38)
Location type
Intronic
Target gene
AIG1
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-218-5p ; hsa-mir-3656 ; hsa-mir-3974 ; hsa-mir-340-3p ; hsa-mir-4293 ; hsa-mir-4434 ; hsa-mir-4516 ; hsa-mir-4531 ; hsa-mir-4786-5p ; hsa-mir-4802-3p ; hsa-mir-5703 ; hsa-mir-6827-3p ; hsa-mir-6849-3p ; hsa-mir-769-5p
Nearest miRNA
hsa-mir-10398/Upstream/2626827; hsa-mir-1202/Downstream/7791965;
Nearest TSS
ENST00000381078/Upstream/145766; ENST00000367592/Downstream/131267;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/249462, chr6-CpG: 40/Downstream/139763
Upstream sequence
TCATATATATGTAGTCAGATCAGACTGTAGAACTATATCAGAAAATTTCATTACCATTTGCAATATGACAAAAGCAGCAGCAAActgagtgttctacatc
Downstream sequence
aagaaaaaaagaaagaatatacaaattattaatataataaatgaaagaggaatcccactactgagcctatggacattaaaagaataataaaggaatatta
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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