Basic Information
VIS ID
TVIS20000505
Fusion event
HPV-TFAP2E integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
36055687/35590086 (Hg38)
End
36055687/35590086 (Hg38)
Location type
Intronic
Target gene
TFAP2E
Nearest miRNA
hsa-mir-12136/Upstream/920392; hsa-mir-101-1/Downstream/1571477;
Nearest TSS
ENST00000473358/Upstream/12357; ENST00000373226/Downstream/41451;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/12243, chr1-CpG: 31/Downstream/51282
Upstream sequence
AAAATTGCTTATACAATTTTTAACAGTTAGAAGGAAATTAGTAAGAGAAAAAAATCTGAAGAAAAATGTTTacatgtgttgggtatttaattgtatgcca
Downstream sequence
ggcactttgctaacctctctatgttgattactaccatttcatgttcacagtaaccttataatggaagattctattattgtctccattttatagatgagaa
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate