Basic Information
VIS ID
TVIS20000507
Fusion event
HPV-KANK4 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
62719915/62254243 (Hg38)
End
62719915/62254243 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
KANK4
miRNAs that regulate target gene
hsa-mir-510-3p ; hsa-mir-1290 ; hsa-mir-103a-2-5p ; hsa-mir-4738-3p ; hsa-mir-6884-3p ; hsa-mir-1207-3p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-448 ; hsa-mir-153-3p ; hsa-mir-3119 ; hsa-mir-6813-5p ; hsa-mir-6085 ; hsa-mir-129-5p ; hsa-mir-3936
Nearest miRNA
hsa-mir-12132/Upstream/175384; hsa-mir-101-1/Downstream/1072682;
Nearest TSS
ENST00000473358/Upstream/59412; ENST00000442679/Downstream/9181;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/58969, chr1-CpG: 103/Downstream/64222
Upstream sequence
AATAAAAATTATCCCTCCCTATTCACTTTGTTGCCCAGACCTATTCCCCAGAAATAGGTACTCTTTTAACAGTAATTATATATCTTCCAATAACTTTCTA
Downstream sequence
TGTTTATAAACATTCACTCCCTATCTGTCTGTTTTTAAAAAACTTAAATGGGTGTTACATATTGCCTTGAGCTTGCATTTTTTCCCCCATCTCAAAAGTG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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