Basic Information
VIS ID
TVIS20000516
Fusion event
HPV-PLD5 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr1
Cytoband
q43
Reference genome
GRCh37/hg19
Start
242508826/242345524 (Hg38)
End
242508826/242345524 (Hg38)
Location type
Intronic
Target gene
PLD5
miRNAs that regulate target gene
hsa-mir-516b-5p ; hsa-mir-4665-3p ; hsa-mir-378a-5p ; hsa-mir-505-5p ; hsa-mir-6823-3p ; hsa-mir-2114-3p ; hsa-mir-3117-5p ; hsa-mir-6730-3p ; hsa-mir-645 ; hsa-mir-1908-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-5684 ; hsa-mir-219a-1-3p ; hsa-mir-8081 ; hsa-mir-627-5p ; hsa-mir-937-5p ; hsa-mir-924 ; hsa-mir-3978 ; hsa-mir-6730-5p ; hsa-mir-329-5p ; hsa-mir-1303 ; hsa-mir-3123 ; hsa-mir-3925-5p ; hsa-mir-4311
Nearest miRNA
hsa-mir-101-1/Upstream/1213178; hsa-mir-3124/Downstream/1000652;
Nearest TSS
ENST00000473358/Upstream/80091; ENST00000439562/Downstream/103901;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/287826, chr1-CpG: 177/Downstream/178090
Upstream sequence
gtatattgcaatatagtaatagaaataaagtgtacaagaaatgtaatgcacttttgaatcattccgtaaaccaacccctactccaggtctgtggaaaaat
Downstream sequence
tatcttccacaaaaccagtcactggtgccaaaaaggttggggatcgctgATACAGTGTCTAGATTTAACTGCAGTTTGTTCTGATTTTATtcaacttttt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
Curate