Basic Information
VIS ID
TVIS20000524
Fusion event
HPV-ADK integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
76162142/74402384 (Hg38)
End
76162142/74402384 (Hg38)
Location type
Intronic
Target gene
ADK
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-5571-5p ; hsa-mir-4674 ; hsa-mir-6878-3p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-6749-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-4437 ; hsa-mir-4757-5p ; hsa-mir-6744-3p ; hsa-mir-378g ; hsa-mir-4680-5p ; hsa-mir-532-3p ; hsa-mir-212-5p ; hsa-mir-6513-3p ; hsa-mir-1224-3p ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-6813-3p ; hsa-mir-498 ; hsa-mir-592 ; hsa-mir-4279 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-597-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-1914-5p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-1265/Upstream/1681284; hsa-mir-107/Downstream/1150074;
Nearest TSS
ENST00000439456/Upstream/225698; ENST00000467840/Downstream/122980;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/225154, chr10-CpG: 35/Downstream/411053
Upstream sequence
tattcaactcacagagttgaaccttcctttagacagagcagatttgaaacactctttttgtggaatttgcaagtggagatttcaagagatttgagaccaa
Downstream sequence
tggtagaaaggaaatatcttcgtataaaaactagacagaatcattctcagaaactactttgtgatgtgtgtgttcaactcacagagtttaacatttctgt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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