Basic Information
VIS ID
TVIS20000531
Fusion event
HPV-NELL1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
21014889/20993343 (Hg38)
End
21014889/20993343 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
NELL1
Nearest miRNA
hsa-mir-210/Upstream/1233260; hsa-let-7a-2/Downstream/2425762;
Nearest TSS
ENST00000527297/Upstream/57647; ENST00000534263/Downstream/269227;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/323044, chr11-CpG: 88/Downstream/1199283
Upstream sequence
CCTTCCTCTGTGTGCCCCTGCTTTTCATCCTCTGTGCCTTTGTGGCTGCTAGCCTTTTCCTTGGCACACCTTTCTTCCCCATCATCTGCAGATTTATACA
Downstream sequence
GGCTTCAGCAGCTGGCTGGTAAACTTTCTCCAGGAGGTTTTCTCAACCCCTTCAGCAGGAAGTAACTCTTAGAGCATGTTATCTGTGTTTCTTTTCCATC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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