Basic Information
VIS ID
TVIS20000540
Fusion event
HPV-NAV3 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr12
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
78077208/77683428 (Hg38)
End
78077208/77683428 (Hg38)
Location type
Intronic
Target gene
NAV3
miRNAs that regulate target gene
hsa-mir-29a-3p ; hsa-mir-21-5p
Nearest miRNA
hsa-let-7i/Upstream/8098605; hsa-mir-1178/Downstream/1735829;
Nearest TSS
ENST00000382841/Upstream/303608; ENST00000549993/Downstream/92355;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/617266, chr12-CpG: 38/Downstream/1120856
Upstream sequence
gaagtagaggtaaaaagtgaagtagcaggagggagagaggataaattaaaaatgaaaaagaatggaatccacagaacaagagaaaggactgaaattttat
Downstream sequence
aaaaaggactttttttcagtgtaataaagtaagaggaaacaggtatggtataggtatgataaaataagaacatttatctaatggttcctattttctcagt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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