Basic Information
VIS ID
TVIS20000659
Fusion event
HPV-FAM172A integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
92993618/93657912 (Hg38)
End
92993618/93657912 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5B ; FRA5D
Target gene
FAM172A
miRNAs that regulate target gene
hsa-mir-421 ; hsa-mir-330-3p ; hsa-mir-218-5p ; hsa-mir-1827 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-6835-3p
Nearest miRNA
hsa-mir-10397/Upstream/37124; hsa-mir-103a-1/Downstream/2421226;
Nearest TSS
ENST00000502646/Upstream/65939; ENST00000606528/Downstream/83725;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/36278, chr5-CpG: 41/Downstream/453336
Nearest cancer related gene
FAM172A(TSG, No orient, 0)
Upstream sequence
ctatgctatcctttgtaggtttaccacctatctaggttttccaacatagcctgtttttaaatggataaatagaatcatgtttcgtatgactttttgtttt
Downstream sequence
AACAACAGTAACCAAATTTGCTATATAATATGCATTGTTATCTTTAAAATAATGCTTCCTATTTTTGATACTTTTTTTGTAAATGAATGGCTATTATCTA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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