Basic Information
VIS ID
TVIS20000660
Fusion event
HPV-MCTP1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr5
Cytoband
q15
Reference genome
GRCh37/hg19
Start
94374260/95038556 (Hg38)
End
94374260/95038556 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA5B
Target gene
MCTP1
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-4446-5p ; hsa-mir-510-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-6505-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-642a-5p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6832-3p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-203a-3p
Nearest miRNA
hsa-mir-10397/Upstream/1417768; hsa-mir-103a-1/Downstream/1040582;
Nearest TSS
ENST00000502646/Upstream/21069; ENST00000506418/Downstream/42926;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/419418, chr5-CpG: 161/Downstream/245199
Upstream sequence
aggctgcagtcacccatgatcacaccactgcactccagcctgggtaacagagtgagaccctgtctccaaaaaaaaaaaaaaaTCCCTTTCTATTTTCCCT
Downstream sequence
cagtggatggagagggaaagagtaaccagagaaacctgacaaactacatcaTGGAAGGCATATTAGTGATAAATGAGCCTAACTCTCTTCACCATCCCTT
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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