Basic Information
VIS ID
TVIS20000676
Fusion event
HPV-GRIK2 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr6
Cytoband
q16.3
Reference genome
GRCh37/hg19
Start
102287260/101839385 (Hg38)
End
102287260/101839385 (Hg38)
Location type
Intronic
Target gene
GRIK2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-1303 ; hsa-mir-3122 ; hsa-mir-3123 ; hsa-mir-3201 ; hsa-mir-3675-5p ; hsa-mir-3913-5p ; hsa-mir-3925-5p ; hsa-mir-450a-1-3p ; hsa-mir-450b-3p ; hsa-mir-4791 ; hsa-mir-5002-5p ; hsa-mir-5089-5p ; hsa-mir-6513-5p ; hsa-mir-6728-5p ; hsa-mir-6751-5p ; hsa-mir-6752-5p ; hsa-mir-6803-5p ; hsa-mir-6835-5p ; hsa-mir-6842-5p ; hsa-mir-6890-5p ; hsa-mir-7110-5p ; hsa-mir-769-3p ; hsa-mir-887-5p
Nearest miRNA
hsa-mir-10398/Upstream/2714689; hsa-mir-1202/Downstream/4944740;
Nearest TSS
ENST00000381078/Upstream/21015; ENST00000487395/Downstream/88394;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/436287, chr6-CpG: 79/Downstream/3019859
Upstream sequence
cctgtaatcccagccacttgggaggctgaggcaggagaatggcttgaacctgggaggcagagattgccgtgagccgagatggtgccattgcactccagca
Downstream sequence
atatatgaataactctaagtagtctaccactgatgtagcacagaaaatgtaagggactggtgatggatgagtgtgaacagataggcaacatcaaagtaga
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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