Basic Information
VIS ID
TVIS20000683
Fusion event
HPV-CUX1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
101904408/102261128 (Hg38)
End
101904408/102261128 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
CUX1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-877-3p ; hsa-mir-455-3p ; hsa-mir-18b-5p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-10525/Upstream/1101573; hsa-mir-10399/Downstream/31975;
Nearest TSS
ENST00000635602/Upstream/106665; ENST00000487284/Downstream/13046;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/11774, chr7-CpG: 177/Downstream/25084
Nearest cancer related gene
CUX1(TSG, No orient, 0)
Upstream sequence
AAAATGTCATCTGCTTTTGTTAACTGGTAACCTGATTTTATTAAATTCCTTAATAGGAGAAATGGTAGCCTTAAAAAAAGTACGTCTGGATAATGAAAAG
Downstream sequence
GGCCCAGCCTTAGGCAGGCATTGCTGAAGTTCCTGTCTTTTCCAAGAAGTTCAGACTCTTAGAATACCAACAGGAAGGGCCCTggtcgagcatggtgggt
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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