Basic Information
VIS ID
TVIS20000695
Fusion event
HPV-FBP1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr9
Cytoband
q22.32
Reference genome
GRCh37/hg19
Start
97382123/94619841 (Hg38)
End
97382123/94619841 (Hg38)
Location type
Intronic
Target gene
FBP1
Nearest miRNA
hsa-let-7a-1/Upstream/440921; hsa-mir-12126/Downstream/190121;
Nearest TSS
ENST00000422679/Upstream/26048; ENST00000427193/Downstream/19666;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/244467, chr9-CpG: 73/Downstream/19229
Nearest cancer related gene
FBP1(TSG, No orient, 0)
Upstream sequence
tccctctgtaaatttattcctttctcagattttctgatgtattattttttgatacattttgtagtcagcttgtcaaattccaattaaaaatcttgttgac
Downstream sequence
CTGAAGAGGGAAGTCACTATCCTCTCTTAATAGACCAGACAGTCCTCACGTCATTGCTACAATTAAATTCCAGAGAATTTTTTGGATTCTATTTAATGAA
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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