Basic Information
VIS ID
TVIS20000715
Fusion event
HPV-PPRC1 integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr10
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
103883153/102123396 (Hg38)
End
103883153/102123396 (Hg38)
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
PPRC1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-98-5p ; hsa-mir-296-3p ; hsa-mir-425-5p ; hsa-mir-186-5p ; hsa-mir-222-3p ; hsa-mir-183-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-107/Upstream/521899; hsa-mir-1307/Downstream/313116;
Nearest TSS
ENST00000439456/Upstream/2943; ENST00000462933/Downstream/9598;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/3036, chr10-CpG: 84/Downstream/9506
Upstream sequence
tcatgaatgaatgaCTCATTCAAGAAAAGGCCCTCCATACTGCTGACTGTTGGAGGATGCTGTCCTCCTTCACAGTGGCCAGTTGAGCATTCACATTGAC
Downstream sequence
TTTCTGTTGCTGCCACTGTATGGGCCATGTTGGAGACAGGATTTGGAAAAGTGGTAGATGGAAGGAAAAGCAGAGAGCACACACTGGGTCCAAGAAGATG
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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