Basic Information
VIS ID
TVIS20000719
Fusion event
HPV-NTM integration
Validated
No
Detection method
HIVID
Data source
Curated
Sample type
Tumor
Disease
Not given
Quality evaluation
Normal
Reported year
2015
PubMed ID
25581428
Virus Sequence
Virus name
HPV
Subtype
HPV16
Reference genome
NC_001526.2
Host Sequence
Chromosome
chr11
Cytoband
q25
Reference genome
GRCh37/hg19
Start
131375845/131505951 (Hg38)
End
131375845/131505951 (Hg38)
Location type
Intronic
Target gene
NTM
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-340-5p ; hsa-mir-501-5p ; hsa-mir-500b-5p ; hsa-mir-362-5p
Nearest miRNA
hsa-let-7a-2/Upstream/839148; hsa-mir-4697/Downstream/2392553;
Nearest TSS
ENST00000527297/Upstream/50488; ENST00000416661/Downstream/34647;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/589212, chr11-CpG: 16/Downstream/184511
Upstream sequence
GCTCCCGGCCTCTCTGGAAAGCCTGGGGGTCCACAGGAAACCTGCCAAACTGCCTCCTTGCCCTGTGGGGGCAGCAACTGTCCCTGTCCTGTCGGCGCTG
Downstream sequence
CTGCATCCTGACCACCCCTCGGCACAGTAAACACACGGCTTGGCGGGGCTTTCCCACATGGGCAGGAAGGAGCTAAGACCCTCAGCTTACTTGGTGCTGC
Reference
Hu, Z., et al. Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism. Nat Genet,2015, 47(2): 158-163.
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